Recent Publications

 

2020

Huang L, Deighan P, Jin J et al.Tombusvirus p19 Captures RNase III-Cleaved Double-Stranded RNAs Formed by Overlapping Sense and Antisense Transcripts in Escherichia coli. mBio 2020 Jun; 11:e00485-20.

Jun H, Liu X, Xia S et al. FDA-approved disulfiram inhibits pyroptosis by blocking gasdermin D pore formation. Nature Immunol 2020 May; Epub ahead of print.

Liu X, Lieberman J. Knocking 'em Dead: Pore-Forming Proteins in Immune Defense. Annu Rev Immunol 2020 Apr; 38:455-485.

Zhang Z, Zhang Y, Xia S, Kong Q, Li S, Liu X, Junqueira C, Meza-Sosa KF, Mok TMY, Ansara J, Sengupta S, Yao Y, Wu H, Lieberman J. Gasdermin E suppresses tumour growth by activating anti-tumour immunity. Nature 2020 Mar; 579:415.

2019

Lieberman J, Wu H, Kagan J. Gasdermin D activity in inflammation and host defense. Sci Immunol 2019 Sep; 4: eaav1447.

Dotiwala F, Lieberman J. Granulysin: killer lymphocyte safeguard against microbes. Curr Opin Immmunol 2019 May; 60:19.

Vu LT, Peng B, Zhang DX, Ma V, Mathey-Andrews CA, Lam CK, Kiomourtzis T, Jin J, McReynolds L, Huang L, Grimson A, Cho WC, Lieberman J, Le MT. Tumor-secreted extracellular vesicles promote the activation of cancer-associated fibroblasts via the transfer of microRNA-125b. J Extracell Vesicles 2019 Apr; 8:1599680.

Tombusvirus p19 captures RNase III-cleaved double-stranded RNAs formed by overlapping sense and antisense transcripts in E. coli. bioRxiv 2019 Jan; doi.org/10.1101/510842.

2018

Radiana T. Trifonova*†, Brooke Bollman, Natasha S. Barteneva and Judy Lieberman*. Myeloid Cells in Intact Human Cervical Explants Capture HIV and Can Transmit It to CD4 T Cells. Frontiers in Immunology 2018 Nov; 9:2719.

Lieberman J. Unveiling the RNA World. New Engl J Med 2018 Sep; 379:1278-80.

Junqueira C, Barbosa CRR, Costa PAC, Teixeira-Carvalho A, Castro G, Sen Santara S, Barbosa RP, Dotiwala F, Pereira B, Antonelli LR, Lieberman J, Gazzinelli RT. Cytotoxic CD8+ T cells recognize and kill Plasmodium vivax-infected reticulocytes. Nat Med 2018 Sep; 24:1330-6.

Hu JJ, Liu X, Zhao J,Xia S, Runa J, Luo X, Kim J, Lieberman J, Wu H. Identification of pyroptosis inhibitors that target a reactive cysteine in gasdermin D. bioRxiv 2018 Jul; doi.org/10.1101/365908.

Meyer SE, Muench DE, Rogers AM, Newkold TJ, Orr E, O’Brien E, Perentesis JP, Doench JG, Lal A, Morris PJ, Thomas CJ, Lieberman J, McGlinn E, Aronow BJ, Salomonis N, Grimes HL. miR-196b target screen reveals mechanisms maintaining leukemia stemness with therapeutic potential. J Exp Med 2018, 215, 2115-36.

Doan M, Vorobjev I, Rees P, Filby A, Wolkenhauer O, Goldfeld AE, Lieberman J, Barteneva N, Carpenter AE, Hennig H. Diagnostic Potential of Imaging Flow Cytometry. Trends Biotechnol 2018 Jul; 36:649-52.

Liu X, Fu R, Pan Y, Meza-Sosa K, Zhang Z, Lieberman J. PNPT1 release from mitochondria during apoptosis triggers decay of poly(A) RNAs. Cell 2018 Jun; 174:187-201.
 

Ruan J, Xia S, Liu X, Lieberman J, Wu H. Cryo-EM structure of the gasdermin A3 membrane pore. Nature 2018 May; 557:62-7.

Clayton KL, Collins DR, Lengieza J, Ghebremichael M, Dotiwala F, Lieberman J, Walker BD. Resistance of HIV-infected macrophages to CD8(+) T lymphocyte-mediatedkilling  drives activation of the immune system. Nat Immunol 2018 May; 19:475-86.

Lieberman J. Tapping the RNA world for therapeutics. Nat Struct Mol Biol 2018 May; 25:357-64.

Kedmi R, Veiga N, Ramishetti S, Goldsmith M, Rosenblum D, Dammes N, Hazan-Halevy I, Nahary L, Leviatan-Ben-Arye S, Harlev M, Behlke M, Benhar I, Lieberman J, Peer D. A modular platform for targeted RNAi therapeutics. Nat Nanotechnol 2018 Mar; 13:214-9.

2017

Chan S, Sridhar P, Kirchner R, Lock YJ, Herbert Z, Buonamici S, Smith P, Lieberman J, Petrocca F. Basal-A Triple-Negative Breast Cancer Cells Selectively Rely on RNA Splicing for Survival. Mol Cancer Ther 2017 Dec; 16:2849-61.

Sula Karreci E, Eskandari SK, Dotiwala F, Routray SK, Kurdi AT, Assaker JP, Luckyanchykov P, Mihali AB, Maarouf O, Borges TJ, Alkhudhayri A, Patel KR, Radwan A, Ghobrial I, McGrath M, Chandraker A, Riella LV, Elyaman W, Abdi R, Lieberman J, Azzi J. Human regulatory T cells undergo self-inflicted damage via granzyme pathways upon activation. JCI Insight 2017 Nov; 2:(21). pii: 91599.

Dotiwala F, Sen Santara S, Binker-Cosen AA, Li B, Chandrasekaran S, Lieberman J. Granzyme B Disrupts Central Metabolism and Protein Synthesis in Bacteria to Promote an Immune Cell Death Program. Cell 2017 Nov; 171:1125-37.

Liu X, Lieberman J. A mechanistic understanding of pyroptosis: the fiery death triggered by invasive infection. Adv Immunol 2017 Apr; 135:87-117.

Su S, Liao J, Liu J, Huang D, He C, Chen F, Yang L, Wi W. Chen J, Lin L, Zeng Y, Ouyang N, Cui X, Yao H, Su F, Huang JD, Lieberman J, Liu Q, Song E. Blocking the recruitment of naive CD4+ T cells reverses immunosuppression in breast cancer. Cell Res 2017 Apr; 27:461-82.

Deruaz M, Murooka TT, Ji S, Gavin MA, Vrbanac VD, Lieberman J, Tager AM, Mempel TR, Luster AD. Chemoattractant-mediated leukocyte trafficking enables HIV dissemination from the genital mucosa.  JCI Insight 2017 Apr; 2:88533.

Liu X, Lieberman J. How ICE lights the pyroptosis fire. Cell Death Differ 2017 Feb; 24:197-9.

2016

Liu X, Zhang Z, Ruan J, Pan Y, Venkat GM, Wu H, Lieberman J. Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores. Nature 2016 Jul; 535:153-8.

 

Wheeler LA, Trifonova RT, Vrbanac V, Barteneva N, Liu X, Bollman B, Onofrey L, Mulik S, Ranjbar S, Luster AD, Tager AM, Lieberman J. TREX1 knockdown induces an interferon response to HIV that delays viral infection in humanized mice. Cell Rep 2016 May;15: 1715-27.

Lieberman J. Cytotoxic lymphocytes. In: Ratcliffe MJH (Editor in Chief), Encyclopedia of Immunobiology 2016 May; 3:363-73. Oxford: Academic Press.

Boulias K, Lieberman J, Greer EL. An epigenetic clock measures accelerated aging in treated HIV infection. Mol Cell 2016 Apr; 62:153-5.

 

Kedersha N, Panas MD, Achorn CA, Lyons S, Tisdale S, Hickman T, Thomas M, Lieberman J, McInerney GM, Ivanov P, Anderson P. G3BP-Caprin1-USP10 complexes mediate stress granule condensation and associate with 40S subunits. J Cell Biol 2016 Mar; 212:845-60.

 

Basu R, Whitlock BM, Husson J, Le Floc'h A, Jin W, Oyler-Yaniv A, Dotiwala F, Giannone G, Hivroz C, Biais N, Lieberman J, Kam LC, Huse M. Cytotoxic T cells use mechanical force to potentiate target cell killing. Cell 2016 Mar; 165:100-10.

 

Dotiwala F, Mulik S, Polidoro RB, Ansara JA, Burleigh BA, Walch M, Gazzinelli RT, Lieberman J. Killer lymphocytes use granulysin, perforin and granzymes to kill intracellular parasites. Nature Medicine 2016 Feb; 22:210-6.

 

Tan SM, Lieberman J. Capture and identification of miRNA targets by biotin pulldown and RNA-seq. Methods Mol Biol 2016 Jan; 1358:211-28.

Perdigão-Henriques R, Petrocca F, Altschuler G, Thomas MP, Le MTN, Tan SM, Hide W, Lieberman J. miR-200 promotes the mesenchymal to epithelial transition by suppressing multiple members of the Zeb2 and Snail1 transcriptional repressor complexes. Oncogene 2016 Jan; 35:158-72.

 

Weinstein S, Toker IA, Emmanuel R, Ramishetti S, Hazan-Halevy I, Rosenblum D, Goldsmith M, Abraham A, Benjamini O, Bairey O, Raanani P, Nagler A, Lieberman J, Peer D. Harnessing RNAi-based nanomedicines for therapeutic gene silencing in B-cell malignancies. Proc Natl Acad Sci USA 2016 Jan; 113:E16-22.

2015

Gilboa-Geffen A, Hamar P, Le MT, Wheeler LA, Trifonova R, Petrocca F, Wittrup A, Lieberman J. Gene knockdown by EpCAM aptamer-siRNA chimeras suppresses epithelial breast cancers and their tumor-initiating cells. Mol Cancer Ther 2015 Oct; 14:2279-91.

 

Wittrup A, Lieberman J. Knocking down disease: a progress report on siRNA therapeutics. Nat Rev Genet 2015 Sep; 16:543-52.

 

Wittrup A, Ai A, Liu X, Hamar P, Trifonova R, Charisse K, Manoharan M, Kirchhausen T, Lieberman J. Visualizing lipid-formulated siRNA release from endosomes and target gene knockdown. Nat Biotechnol 2015 Aug; 33:870-6.

 

Navarro F, Lieberman J. miR-34 and p53: new insights into a complex functional relationship. PLoS One 2015 Jul;1 0:e0132767.

 

Lieberman J. Manipulating the in vivo immune response by targeted gene knockdown. Curr Opin Immunol 2015 Jul; 35:63-72.

 

Dotiwala F, Fellay I, Filgueira L, Martinvalet D, Lieberman J, Walch M. A high yield and cost-efficient expression system of human granzymes in mammalian cells. J Vis Exp 2015 Jun; 100:e52911.

 

O'Day E, Lee MT, Imai S, Tan SM, Kirchner R, Arthanari H, Hofmann O, Wagner G, Lieberman J. An RNA-binding protein, Lin28, recognizes and remodels G-quartets in the miRNAs and mRNAs it regulates. J Biol Chem 2015 Jun; 290:17909-22.

 

Thomas MP, LiuX, Whangbo J, McCrossan G, Sanborn KB, Basar E, Walch M, Lieberman J. Apoptosis triggers specific, rapid, and global mRNA decay with 3'uridylated intermediates degraded by DIS3L2. Cell Rep 2015 May; 11:1079-89.

 

Sharei A, Trifonova R, Jhunjhunwala S, Hartoularos GC, Eyerman AT, Lytton-Jean A, Angin M, Sharma S, Poceviciute R, Mao S, Heimann M, Liu S, Talkar T, Khan O, Addo M, von Andrian UH, Anderson DG, Langer R, Lieberman J, Jensen K. Ex Vivo cytosolic delivery of functional macromolecules to immune cells. PLoS One 2015 Apr; 10:e0118803.

 

Luo ML, Chang G, Chen CH,  Hu H, Huang P, Zheng M, Yao Y, Wei S, Wulf G, Lieberman J, Zhen Zhou X, Song E, Lu KP. The Rab2A GTPase promotes breast cancer stem cells and tumorigenesis via Erk signaling activation. Cell Rep 2015 Apr; 11:111-24.

 

Lieberman J, Sharp P. Harnessing RNA interference for therapy: the silent treatment. JAMA 2015 Mar; 313:1207-8.

 

Hata A, Lieberman J. Dysregulation of microRNA biogenesis and gene silencing in cancer. Sci Signal 2015 Mar; 8:re3.

 

Jacquemin G, Margiotta D, Kasahara A, Bassoy EY, Walch M, Thiery J, Lieberman J, Martinvalet D. Granzyme B-induced mitochondrial ROS are required for apoptosis. Cell Death Differ 2015 May; 22:862-74.

 

2014

Ivanov P, O'Day E, Emara MM, Wagner G, Lieberman J, Anderson P. G-quadruplex structures contribute to the neuroprotective effects of angiogenin-induced tRNA fragments. Proc Natl Acad Sci USA 2014 Dec 23;111:18201-6.

 

Le M, Hamar P, Guo C, Basar E, Perdigao-Henriques R, Balaj L, Lieberman J. miR-200-containing extracellular vesicles promote breast cancer cell metastasis. J Clin Invest 2014 Dec;124:5109-28.

 

Tan S, Kirchner R, Jin J, Hofmann O, McReynolds L, Hide W, Lieberman J. Sequencing of captive target transcripts identifies the network of regulated genes and functions of primate-specific miR-522. Cell Rep 2014 Aug 21;8:1225-39.

 

Tay Y, Tan SM, Karreth F, Lieberman J, Pandolfi PP. Characterization of dual PTEN and p53-targeting microRNAs identifies miR-638/Dnm2 as a two-hit oncogenic locus. Cell Rep 2014 Aug 7;8:714-22.

 

Luo M-L, Gong C, Chen C-H, Lee DY, Hu H, Huang P, Yao Y, Guo W, Reinhardt F, Wulf G, Lieberman J, Zhou XZ, Song E, Lu KP. Prolyl isomerase Pin1 acts downstream of miR-200 to promote cancer stem-like cell traits in breast cancer. Cancer Res 2014 Jul 1;74:3603-16.

 

Walch M, Dotiwala F, Mulik S, Thiery J, Kirchhausen T, Clayberger C, Krensky A, Martinvalet D, Lieberman J. Cytotoxic cells kill intracellular bacteria through granulysin-mediated delivery of granzymes. Cell 2014 Jun 5;157:1309-23.

 

Thomas MP, Whangbo J, McCrossan G, Deutsch A, Martinod K, Walch N, Lieberman J. Leukocyte protease binding to nucleic acids promotes nuclear localization and cleavage of nuclear binding proteins. J Immunol 2014 Jun 1;192:5390-7.

 

Trifonova RT, Lieberman J*, van Baarle D*. Distribution of immune cells in the human cervix and implications for HIV transmission. Am J Reprod Immunol 2014 Mar;71:252-64.

 

Thiery J, Lieberman J. Perforin - A Key Pore-forming Protein for Immune Control of Viruses and Cancer. Chapter in "Pore formation by MACPF/CDC proteins - agents of defense, attack and invasion," Anderluh G and Gilbert R, eds. Springer, Dordrecht. Subcell Biochem 2014;80:197-220.

 

2013

Huang L, Lieberman J. Production of highly potent recombinant siRNAs in Escherichia coli. Nat Protoc 2013 Dec;8:2325-36.

 

Tuli A, Thiery J, James AM, Michelet X, Sharma M, Garg S, Sanborn KB, Orange JS, Lieberman J, Brenner MB. Arf-like GTPase Arl8b regulates lytic granule polarization and natural killer cell-mediated cytotoxicity. Mol Biol Cell 2013 Dec;24:3721-35.

 

Petrocca F, Altschuler G, Tan SM, Mendillo ML, Yan H, Jerry DJ, Kung Al, Hide W, Ince TA, Lieberman J. A Genome-wide siRNA screen identifies proteasome addiction as a vulneratility of basal-like triple-negative breast cancer cells. Cancer Cell 2013 Aug 12;24(2):182-96.

 

Wheeler LA, Vrbanac V, Trifonova R, Brehm M, Gilboa-Geffen A, Tanno S, Greiner DL, Luster AD, Tager AM, Lieberman J. Durable knockdown and protection from HIV transmission in humanized mice treated with gel-formulated CD4 aptamer-siRNA chimeras. Mol Ther 2013 Jul;21(7):1378-89.

 

Huang L, Jin J, Deighan P, Kiner E, McReynolds L, Lieberman J. Efficient and specific gene knockdown by small interfering RNAs produced in bacteria. Nat Biotechnol 2013 Apr;31(4):350-6.

 

Lee MN, Roy M, Ong S-E, Mertins P, Villani A-C, Li W, Dotiwala F, Sen J, Doench JG, Orzalli MH, Kramnik I, Knipe DM, Lieberman J, Carr SA, Hacohen N. Identification of regulators of the innate immune response to cytosolic DNA and retroviral infection by an integrative approach. Nat Immunol 2013 Feb;14(2):179-85.

 

Lieberman J. Noncoding RNAs and cancer: knockout punch for cancer. Cell 2013 Mar 28;153(1):9-10.

 

Lieberman J, Sarnow P. Micromanaging hepatitis C virus. N Eng J Med 2013 May 2;368(18):1741-3.

 

Thomas MP, Lieberman J. Live or let die: post-transcriptional gene regulation in cell stress and cell death. Immunol Rev 2013 May;253(1):237-52.

 

Lieberman J. "Cell-mediated cytoxicity," Chapter 37 in Paul WE, Fundamental Immunology, 7th edition, Lippincott, Williams & Wilkins, 2013;891-909.

 

2012

Rajani DK, Walch M, Martinvalet D, Thomas MP, Lieberman J. Alterations in RNA processing during immune-mediated programmed cell death. Proc Natl Acad Sci USA 2012;109(22):8688-93.

 

Yao Y-D, Sun T-M, Huang S-Y, Dou S, Lin L, Chen J-N, Ruan J-B, Mao C-Q, Yu F-Y, Zeng M-S, Zang J-Y, Liu Q, Su F-X, Zhang P, Lieberman J, Wang J, Song E. Targeted delivery of PLK1-siRNA by ScFv suppresses Her2+ breast cancer growth and metastasis. Sci Transl Med 2012;4(130):130ra48.

 

Kang H, Davis-Dusenbery BN, Nguyen PH, Lal A, Lieberman J, Van Aeist L, Lagna G, Hata A. Bone morphogenetic protein 4 promotes vascular smooth muscle contractility by activating microRNA-21 (miR-21), which down-regulates expression of family of dedicator of cytokinesis (DOCK) proteins. J Biol Chem 2012;287(6):3976-86.

 

Yan N, Lieberman J. SAMHD1 does it again, now in resting T cells. Nat Med 2012;18(11):1611-2.

 

2011

Lal A, Thomas MP, Altschuler G, Navarro F, O’Day E, Li XL, Concepcion C, Han Y-C, Thiery J, Rajani D, Deutsch A, Hofmann O, Ventura A, Hide W, Lieberman J. Capture of microRNA-bound mRNAs identifies the tumor suppressor miR-34a as a regulator of growth factor signaling. PLoS Genet 2011;7(11):e1002363.

 

Tay Y, Kats L, Salmena L, Weiss D, Tan SM, Ala U, Karreth F, Poliseno L, Provero P, Di Cunto F, Lieberman J, Rigoutsos I. Coding-independent regulation of the tumor suppresor PTEN by competing endogenous mRNAs. Cell 2011;147:344-57. 

 

Le MTN, Ng S-C, Khaw SL, Chin L, The C, Tay J, O’Day E, Korzh V, Yang H, Lal A, Lieberman J, Lodish HF, Lim B. Conserved regulation of p53 network dosage by microRNA-125b occurs through evolving miRNA-target gene pairs. PLoS Genet 2011;7(9):e1002242.

 

Lakhashe SK, Velu V, Sciaranghella G, Siddappa NB, DiPasquale JM, Hemashettar G, Yoon JK, Rasmussen RA, Yang F, Lee SJ, Montefiori DC, Novembre FJ, Villinger F, Amara RR, Kahn M, Hu S-L, Li S, Li Z, Frankel FR, Robert-Guroff M, Johnson WE, Lieberman J, Ruprecht  RM. Prime-boost vaccination with heterologous live vectors against SIV gag and multimeric HIV-1 gp160 immunization: efficacy against mucosal R5 clade C SHIV challenges. Vaccine 2011;29(34):5611-22.

 

Thiery J, Keefe D, Boulant S, Boucrot E, Walch M, Martinvalet D, Coping IS, Bleackley RC, Kirchhausen T, Lieberman J. Perforin pores in the endosomal membrane trigger release of granzyme B to the cytosol of target cells. Nat Immunol 2011;12:770-7.

 

Yan N, O'Day E, Wheeler LA, Engelman A, Lieberman J. HIV DNA is heavily uracilated, which protects it from autointegration. Proc Natl Acad Sci USA 2011;108:9244-9.

 

Wheeler LA, Trifonova R, Vrbanac V, Basar E, McKernan S, Xu Z, Seung E, Deruaz M, Dudek T, Einarsson JI, Yang L, Allen TM, Luster AD, Tager AM, Dykxhoorn DM, Lieberman J. Inhibition of HIV transmission in human cervicovaginal explants and humanized mice using CD4 aptamer-siRNA chimeras. J Clin Invest 2011;121:2401-12.

 

Whitney JB, Mirshahidi S, Lim S-Y, Goins L, Frankel FR, Ibegbu CC, Anderson DC, Raybourne RB, Lieberman J, Ruprecht RM. Prior Exposure to an attenuated Listeria vaccine does not reduce immunogenicity: pre-clinical assessment of the efficacy of a Listeria aaccine in the induction of immune responses to HIV. J Immune Based Ther Vaccines 2011;9:2.

 

Peer D, Lieberman J. Special delivery: targeted delivery with small RNAs. Gene Ther 2011 Dec;18(12):1127-33.

 

Yan N, Lieberman J. Gaining a foothold: how HIV evades innate immunity. Curr Opin Immunol 2011;23(1):21-8.

 

Petrocca F, Lieberamn J. The promise and challenge of RNA interference-based therapy for cancer. J Clin Oncol 2011;29:747-54.

 

2010

Yan N, Regalado-Magdos, AD, Stiggelbout B, Lee-Kirsch MA, Lieberman J. The cytosolic exonuclease TREX1 inhibits the innate immune response to human immunodeficiency virus type 1. Nat Immunol 2010;11:1005-13.

 

Niland B, Miklossy G, Banki K, Biddison WE, Casciola-Rosen L, Rosen A, Martinvalet D, Lieberman J, Perl A. Cleavage of transaldolase by granzyme B causes the loss of enzymatic activity with retention of antigenicity for multiple sclerosis patients. J Immunol 2010;184:4025-32.

 

Thiery J, Walch M, Jensen DK, Martinvalet D, Lieberman J. Isolation of cytotoxic T cell and NK granules and purification of their effector proteins. Curr Protoc Cell Biol 2010 Jun;Chapter 3:Unit3.37:1-29.

 

Thiery J, Keefe D, Saffarian S, Martinvalet D, Walch M, Boucrot E, Kirchhausen T, Lieberman J. Perforin activates clathrin and dynamin-dependent endocytosis, which is required for plasma membrane repair and delivery of granzyme B for granzyme-mediated apoptosis. Blood 2010;115:1582-93.

 

Chan MC, Hilyard AC, Wu C, Davis BN, Hill NS, Lal A, Lieberman J, Lagna G, Hata A. molecular basis for antagonism between PDGF and TGFb-family signaling pathways by control of miR-24 expression. EMBO J 2010;29:559-73. 

 

Thomas MP, Lieberman J, Lal A. Desperately seeking microRNA targets. Nat Struct Mol Biol 2010;17:1169-74.

 

Lieberman J. Master of the cell. The Scientist 2010;24:43-8.

 

Navarro F, Lieberman J. Small RNAs guide hematopoietic cell differentiation and function. J Immunol 2010;184:5939-47.

 

Lieberman J. Granzyme A activates another way to die. Immunol Rev 2010;235:93-104.

 

Lieberman J. Anatomy of a murder: how cytotoxic T cells and NK cells are activated, develop and eliminate their targets. Immunol Rev 2010;235:5-9.

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